WebBufalin is a cardiotonic steroid toxin originally isolated from Chinese toad venom, which is a component of some traditional Chinese medicines. Research. Bufalin has in vitro … WebOct 2, 2015 · Bufalin has poor aqueous solubility, hindering its clinical use. P-Buf developed in this study is a prodrug derivative whose charged phosphate group significantly enhances its aqueous solubility. …
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WebWe offer qualified product Bufalin (465-21-4), please inquire us for Bufalin (465-21-4). Shopping Cart 0. Toggle ... Bufalin (BUF) exhibits promising potential for the treatment of various human cancers. However, its poor water solubility and unsatisfying stability in water limit its further clinical applications. In the current study, we ... WebDec 22, 2024 · Bufalin 3-phosphate (Figure 7a) is a water-soluble prodrug that could solve the problem of water solubility of BF and facilitate its administration in vivo. Furthermore, bufalin 3-phosphate was also demonstrated to effectively inhibit tumor growth in an orthotopic triple negative breast cancer (TNBC) mouse model [ 84 ].
WebBufalin C24H34O4 CID 9547215 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity … WebNov 29, 2024 · Bufalin (BFL) has excellent physiological activities such as defending tumors, improving cardiac function, and so on. However, due to its poor water-solubility and bioavailability, the clinical application of BFL remains limited. In order to improve bioavailability of BFL, in our previous research, a novel peptide-dendrimer (PD) was …
WebJul 27, 2012 · The saturate solubility of bufalin was 32.76 μg/mL in pH 7.0 and 29.86 μg/mL in pH 7.8–8.0. 37 The volume of medium was three times the saturated solution of bufalin. For comparing the sustained-release properties of free bufalin, bufalin-mPEG-PLGA-PLL NPs, and bufalin-mPEG-PLGA-PLL-cRGD NPs, a dialysis tube (molecular … WebJul 5, 2024 · Bufalin, derived from Venenum Bufonis, exerts antitumor effects but has low bioavailability and adverse effects when administered as a single agent. The purpose of this study was to evaluate the physical and chemical properties, antitumor efficacy, general pharmacology, acute toxicity, and tissue distribution profile of bufalin-loaded PEGylated …
WebJun 13, 2024 · Bufalin is a traditional Chinese medication derived from toad venom with pronounced anti-tumor, analgesic, and anti-inflammatory properties. However, poor solubility, rapid metabolism together with the knowledge gap on its pain alleviation mechanism have limited the clinical application of bufalin.
WebJan 1, 2024 · In this work, we used the small angle X-ray scattering (SAXS) method for controlled preparation of in situ forming sustained-release carriers for the antitumor drug bufalin (BUF), which has very poor solubility and a considerable cardiotoxicity in a non-encapsulated state. To that aim, we exploited the pseudo-ternary phase diagram of an … picture converter to svgWebOct 25, 2024 · Bufalin (buf) has poor solubility in aqueous solution, poor tumor targeting, and many non-specific toxic and side effects. The advantages of high-molecular-weight polymer conjugates are that they can improve the water solubility of buf, prolong plasma half-life, and reduce non-specific toxicity. A novel water-soluble polymer–drug conjugate … picture computer engineeringWebBufalin is an anti-metastasis drug [ 4], which elicits anti-tumor functionality by favoring cell cycle arrest and apoptosis in various cancer types including hepatocellular, bladder and osteosarcoma. [ 2] It also promotes autophagic cell death and possesses anti … picture control utility 2 nikonWebBufalin (0, 1, 2, 4 μM for 48 hours) decreases cell viability in NCI-H460 cells. Bufalin (2 μM) increases caspae-3, Endo G and GADD153 mRNA expression, but decreases the GRP78 mRNA expression. MCE has not … picture convert to 1x1WebNov 15, 2024 · Bufalin (BU) is one of the most effective antitumor active constituents in Chansu. Our previous study found that BU can effectively reverse P-glycoprotein (P-gp)-mediated MDR in colon cancer. However, the clinical application of BU is limited due to its low solubility in water and high toxicity. top coworking companies in the worldWebThe bufalin-loaded PEGylated liposomes were developed to improve the solubility and increase the drug concentration in plasma. Significant improvements of solubility and concentration were observed by comparing ration of t 1/2 and AUC (0–t) to bufalin between bufalin-loaded PEGylated liposomes and bufalin-loaded liposomes. picture converter to 1x1WebJul 27, 2012 · Bufalin-loaded mPEG-PLGA-PLL-cRGD nanoparticles: preparation, cellular uptake, tissue distribution, and anticancer activity. Background: Recent studies have shown that bufalin has a good antitumor effect but has high toxicity, poor water solubility, a short half-life, a narrow therapeutic window, and a toxic dose that is close to … top coworker christmas gifts