Human glutamyl carboxylase
Web24 Oct 2014 · Abstract Vitamin K-dependent γ-glutamyl carboxylase (GGCX) is an enzyme that catalyzes the conversion of glutamic acid to gamma-carboxyglutamic acid in substrate proteins. Among GGCX target proteins, recent evidence indicates that osteocalcin regulates insulin sensitivity and secretion. Web1 Aug 2000 · The carboxylase is an integral membrane glycoprotein that uses vitamin K to modify clusters of glutamyl residues (glu's) to γ-carboxylated glutamyl residues (gla's) …
Human glutamyl carboxylase
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Web20 Dec 2005 · Vitamin K gamma glutamyl carboxylase Gene names Name GGCX Synonyms GC Organism names Organism Homo sapiens (Human) Taxonomic identifier … WebDescription: Homo sapiens gamma-glutamyl carboxylase (GGCX), transcript variant 2, mRNA. (from RefSeq NM_001142269) RefSeq Summary (NM_001142269): This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a …
Web8 Jun 2024 · Mammalian cells as the main host for production of human proteins are incapable of complete γ-carboxylation of over-expressed Vitamin K Dependent (VKD) proteins. The Drosophila γ-glutamyl carboxylase (DγC) has been shown to be more efficient than its human counterpart in γ-carboxylation of human substrates, in vitro. WebReaction: EC# Pathway(s) needing this reaction: a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-glycine) tetrapeptide → a mature peptidoglycan with (L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-glycine) tetrapeptide + di-trans,octa-cis-undecaprenyl diphosphate + H +[none] peptidoglycan maturation (meso-diaminopimelate …
WebIt occurs primarily in proteins involved in the blood clotting cascade, specifically factors II, VII, IX, and X, protein C, and protein S, and also in some bone proteins. This modification is required for these proteins to function. Carboxylation occurs in the liver and is performed by γ-glutamyl carboxylase (GGCX). [14] WebThe carboxylase is an integral membrane glycoprotein that uses vitamin K to modify clusters of glutamyl residues (glu's) to γ-carboxylated glutamyl residues (gla's) post-translationally in vitamin K–dependent (VKD) proteins as they pass through the endoplasmic reticulum. Carboxylation is required for VKD protein functions in hemostasis, bone …
Web抗GGCX抗体 ウサギ宿主抗体 Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution; Synonyms: Anti-Gamma-glutamyl carboxylase,Anti-Vitamin K gamma glutamyl carboxylase,Anti-Vitamin K-dependent gamma-carboxylase; find Sigma-Aldrich-HPA018284 MSDS, related peer-reviewed …
Web1 Sep 2001 · The vitamin K-dependent gamma-glutamyl carboxylase catalyzes the posttranslational modification of select glutamate residues of its vitamin K-dependent … graphics card in device managerWebVitamin K-dependent γ-glutamyl carboxylase is a 758 amino acid integral membrane glycoprotein that catalyzes the post-translational conversion of certain protein glutamate residues to γ-carboxyglutamate. Carboxylase … chiropractor 28277WebThe Drosophila γ-glutamyl carboxylase (dγC) has substrate recognition properties similar to that of the vertebrate γ-carboxylase (γC), and its carboxylated product yield, in vitro, … chiropractor 32244graphics card in bang and olufsen envyWebDownload scientific diagram The hydrophobicity profile (A) and membrane topology (B) of human -glutamyl carboxylase. Cysteine residues are marked, and the gray areas correspond to the ... chiropractor 29464Web25 Mar 2004 · A mutation (W501S) in the vitamin K‐dependent γ‐glutamyl carboxylase (VKC) that leads to a congenital bleeding disorder was recently discovered in two patients. To characterize the enzyme defect, recombinant VKC‐W501S was expressed in and purified from insect cells. chiropractor 30033Web10 Feb 1995 · Abstract. We have used two complementary approaches to analyze the chromosomal location of the {gamma}-glutamyl carboxylase gene. The amplification of a carboxylase-specific genomic fragment by polymerase chain reaction (PCR) in a human-rodent hybrid cell mapping panel localized the gene to chromosome 2. chiropractor 30305