WebWe used α-Latrotoxin (α-LTx), the main neurotoxic component of the black widow spider venom, which causes degeneration of the neuromuscular junction (NMJ) followed by a rapid and complete regeneration, as a molecular tool to identify by RNA transcriptomics factors contributing to the structural and functional recovery of the NMJ. We found that Urocortin … WebSome nerve gases used for military purposes act in the same way. a -Latrotoxin , a protein produced by the black widow spider induces massive acetylcholine release while Botulinus Toxin , consisting or a mixture of eight proteins produced by Clostridium botulinum, inhibits the release of acetylcholine at the neuromuscular junction.
Neurexins: synaptic cell surface proteins related to the alpha ...
Webalpha-Latrotoxin (alpha-LTX) from black widow spider venom induces exhaustive release of neurotransmitters from vertebrate nerve terminals and endocrine cells. This 130-kDa protein has been employed for many years as a molecular tool to study exocytosis. Webhippocampal neurons, Lphn2 maintained synapse numbers via a postsynaptic instead of a presynaptic mechanism, which was surprising given its presumptive role as an α-latrotoxin receptor. In CA1-region neurons in vivo, Lphn2 was specifically targeted to dendritic spines in the stratum lacunosum-moleculare, which form synapses with presynaptic portsmouth playzone
Three models of stimulation of exocytosis by α-latrotoxin: …
WebAbstract α-Latrotoxin, a potent neurotoxin from black widow spider venom, triggers synaptic vesicle exocytosis from presynaptic nerve terminals. α-Latrotoxin is a large … Web13 Apr 2024 · HIGHLIGHTS who: Samuele Negro from the Eight to ten week-old , mice were employed for laser capture microdissection (LCM) and transcriptional profiling, and for electrophysiological recordingsC BL/, mice expressing cytosolic … Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor … Web26 Jun 2003 · One family of cell-surface proteins implicated in synapse formation and adhesion is the neurexins. Originally identified by their binding to α-latrotoxin 5 (a spider toxin that triggers ... portsmouth players 2022