2024 Pupylation in mycobacteria

Pupylation in mycobacteria

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August undefined, 2024

WebJun 1, 2015 · Pupylation, the covalent attachment of Pup to proteins, was the first protein-protein modification discovered in prokaryotes. This posttranslational modification has … WebOct 25, 2024 · In this modification pathway termed pupylation, mycobacteria (and other actinobacteria) make use of the small ubiquitin-like protein Pup to target proteins for degradation by the bacterial ...

Structures of Pup ligase PafA and depupylase Dop from the …

WebJul 7, 2014 · Mycobacteria regulate cell proliferation via atypical mechanisms, including protein processing, phosphorylation of unique targets and pupylation (which is analogous … WebThe pupylation of cellular proteins plays a crucial role in the degradation cascade via the Pup-Proteasome system ... the autopupylation of PafA (the sole Pup ligase found in … cd tropezon vs racing rioja cf

The genetic proteome: Using genetics to inform the proteome of …

WebAug 16, 2015 · However, our results indicate that pupylation of an already pupylated protein is unlikely to occur due to low affinity of PafA for such species. This alone prevents predominance of poly- over mono-pupylation in vitro. This effect is likely to be magnified in vivo by the combination of PafA kinetics with the high abundance of non-pupylated proteins. WebApr 15, 2014 · Multidimensional protein identification technology (MudPIT) and MALDI-TOF-MS/MS of the elution fraction unraveled 55 proteins being pupylated in C. glutamicum and 66 pupylation sites. Similar to mycobacteria, the majority of pupylated proteins are involved in metabolism or translation. WebMar 27, 2014 · Pupylation is one of the most important post-translational modifications of prokaryotic proteins playing a key role in regulating a wild range of biol… cd travel katalog 2022

Pupylated proteins in Corynebacterium glutamicum revealed by …

The Pup-Proteasome System of Mycobacteria. - Europe PMC

WebMar 11, 2015 · Master Scientist. Reynolds American Inc. Oct 2024 - Present2 years 7 months. United States. Master Scientist in R&D. Analytical Chemist in the Product Science group. WebOver the past decade the number and variety of eiweiss post-translational modifications is have been detected and characterized int bacteria have rapidly increased. Most post … cdtu centar za digitalnu transformacijuWebOver the past per the number both sort the eiweis post-translational modifications that have become detected and characterized in bacteria have rapidly increased. Most post … cd tribe\u0027s

"WebAug 1, 2015 · A recent study in Msm provided an interesting explanation for the role of pupylation and proteasome-mediated degradation in non-pathogenic mycobacteria (131). … " - Pupylation in mycobacteria

Pupylation in mycobacteria

Reconstitution of the Mycobacterium tuberculosis pupylation …

WebJan 7, 2024 · Both targeted and non-targeted proteomics methods have identified protein posttranslational modifications (PTM) in mycobacteria. Mycobacteria use PTMs to regulate protein function and activity. Glycosylation, phosphorylation, lipidation, formylation, pupylation, acetylation, and methylation have been identified in M. tuberculosis [88,89]. WebAbstract Pupylation is a post-translational protein modification occurring in actinobacteria through which the small, intrinsically disordered protein Pup ... The pupylation pathway …

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WebJun 30, 2009 · Taken together, our data demonstrated the presence of spore particles in old stock cultures of Mm and most likely also in old Mycobacterium bovis bacillus … WebAug 21, 2012 · Pupylation is a posttranslational protein modification occurring in mycobacteria and other actinobacteria that is functionally analogous to ubiquitination. Here we report the crystal structures of ...

WebWeber-Ban, Eilika. dc.date.accessioned. 2024-04-11T14:43:52Z WebApr 10, 2024 · SIRT2 inhibition by AGK2 enhances mycobacteria-specific stem cell memory responses by modulating beta-catenin and glycolysis

WebApr 22, 2024 · In mycobacteria and many other actinobacteria, covalent modification of proteins with the small (60–70 residues), ... known pupylation substrates only accumulate … WebPupylation has also recently been proposed to regulate iron homeostasis in Corynebacterium glutamicum. Interestingly, this bacterial species lacks both subunits of …

WebFeb 8, 2011 · Background. A significant number of cases of granulomatous lymphadenitis have an identifiable underlying cause. The differential diagnosis includes malignancy (Hodgkin's lymphoma and non-Hodgkin's lymphoma), infections (tuberculosis (TB), non-tuberculous mycobacteria, cat scratch disease, fungal infection, sarcoidosis and bacterial …

WebNov 16, 2009 · Mycobacteria have an unusually large number of enzymes involved in fatty acid biosynthesis (roughly 5 times that of E. coli) and must balance de novo synthesis of normal length fatty acyl components of the plasma membrane with the considerably longer mycolic acids that are components of the mycobacterial outer cell envelope. 18 Mycolic … cdtrojan smartbenWebMycobacterium tuberculosis (M. tb), also known as Koch's bacillus, is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of … cdt to beijing timeWebMay 20, 2016 · The modification process is defined as pupylation and is associated with proteasome-mediated protein degradation in mycobacteria and streptomycetes. Here, we … cd t\u0027WebNational Center for Biotechnology Information cd trivema navalWebIn a manner similar to ubiquitin, the prokaryotic ubiquitin‐like protein (Pup) has been shown to target proteins for degradation via the proteasome in mycobacteria. However, not all actinobacteria po... cd trojanWebPup, a small modifier protein, is attached to target proteins by PafA, the sole Pup‐ligase, in a process termed pupylation. In mycobacteria, including Mycobacterium smegmatis and … cd trojan okta login cdtv king\u0026prince